ກົນໄກຂອງການຜຸພັງ squalene ແມ່ນຢູ່ໃນໄລຍະເວລາທີ່ມີຄວາມສ່ຽງຕ່ໍາຂອງມັນໂດຍບໍ່ທໍາລາຍປະຕິກິລິຍາໂມເລກຸນຂອງ hydroperoxides ໃນເສັ້ນທາງ Peroxidation Peroxidation. Studies have shown that the peroxidation of sebum is mainly caused by singlet oxygen, and the singlet oxygen quenching rate constant of squalene in human sebum is much larger than that of other lipids in human skin. extinction constant. However, it should be noted that although squalene can block lipid peroxidation, the products of squalene, such as unsaturated fatty acids, also have an irritating effect on the skin.